SALIVARY Na, K AND Cl SECRETION RATES: RELATIONSHIP TO A FLUID GENERATION MECHANISM
نویسندگان
چکیده
منابع مشابه
The salivary gland fluid secretion mechanism.
Fluid secretion by exocrine glands requires the coordinated activity of multiple water and ion transporter and channel proteins. The molecular cloning of many of the transporter molecules involved in fluid secretion has yielded a better understanding of the fluid secretion process. Mouse salivary glands are easily accessible model systems for the study of exocrine gland secretion at the cellula...
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In rat kidney the "secretory" isoform of the Na+-K+-2Cl- cotransporter (NKCC1) localizes to the basolateral membrane of the alpha-intercalated cell. The purpose of this study was to determine whether rat outer medullary collecting duct (OMCD) secretes Cl- and whether transepithelial Cl- transport occurs, in part, through Cl- uptake across the basolateral membrane mediated by NKCC1 in series wit...
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Water-handling epithelia are sensitive to the osmotic environment. In this study, the effects of a hypo-osmotic challenge on carbachol (CCh)-induced fluid secretion was investigated using an ex vivo submandibular gland perfusion technique and intracellular pH and Ca(2+) measurements. The osmolality of the perfusion solution was altered to examine the response of the gland to a hypotonic challen...
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We hypothesized that cation-dependent Cl- transport protein Na-K-Cl cotransporter isoform 1 (NKCC1) plays a role in the disruption of ion homeostasis in cerebral ischemia. In the current study, a role for NKCC1 in neuronal death was elucidated in neurotoxicity induced by glutamate and oxygen and glucose deprivation (OGD). Incubation of cortical neurons cultured for 14-15 d in vitro (DIV) with 1...
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ژورنال
عنوان ژورنال: The Japanese Journal of Physiology
سال: 1970
ISSN: 1881-1396,0021-521X
DOI: 10.2170/jjphysiol.20.540